Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 327550
Title Baeyer-Villiger monooxygenases, an emerging family of flavin-dependent biocatalysts
Author(s) Kamerbeek, N.M.; Janssen, D.B.; Berkel, W.J.H. van; Fraaije, M.W.
Source Advanced Synthesis and Catalysis 345 (2003)6-7. - ISSN 1615-4150 - p. 667 - 678.
Department(s) Biochemistry
Publication type Refereed Article in a scientific journal
Publication year 2003
Keyword(s) p-hydroxybenzoate hydroxylase - rna differential display - cyclohexanone monooxygenase - escherichia-coli - gene-cluster - steroid monooxygenase - formate dehydrogenase - coenzyme specificity - acinetobacter sp - pseudomonas sp
Abstract Baeyer-Villiger monooxygenases (BVMOs) are flavoenzymes that catalyze a remarkably wide variety of oxidative reactions such as regio- and enantioselective Baeyer-Villiger oxidations and sulfoxidations. Several of these conversions are difficult to achieve using chemical approaches. Due to their selectivity and catalytic efficiency, BVMOs are highly valuable biocatalysts for the synthesis of a broad range of fine chemicals. For a long time, only one member of this class of flavin-containing biocatalysts had been cloned and overexpressed which has limited their application for synthetic processes. Recently a number of new genes that encode BVMOs have been sequenced and overexpressed. In this paper the biocatalytic properties of recently cloned BVMOs are reviewed. Furthermore, the potential for obtaining novel BVMOs from sequenced genomes will be discussed.
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