Staff Publications

Staff Publications

  • external user (warningwarning)
  • Log in as
  • language uk
  • About

    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 327745
Title Modulation of the chicken immune cell function by dietary polyunsaturated fatty acids
Author(s) Sijben, J.W.C.
Source Wageningen University. Promotor(en): Bas Kemp, co-promotor(en): Henk Parmentier; Johan Schrama. - [S.l.] : S.n. - ISBN 9789058085528 - 155
Department(s) Adaptation Physiology
Aquaculture and Fisheries
Publication type Dissertation, internally prepared
Publication year 2002
Keyword(s) hennen - kippen - meervoudig onverzadigde vetzuren - hennenvoeding - voedertoevoegingen - immuniteitsreactie - immuunsysteem - immuniteit - voedingsstoffenverbetering - voedingsfysiologie - diergezondheid - hens - fowls - polyenoic fatty acids - hen feeding - feed additives - immune response - immune system - immunity - nutrient improvement - nutrition physiology - animal health
Categories Poultry

Polyunsaturated fatty acids (PUFA) possess a wide range of biological properties, including immunomodulation. The amount, type, and ratio of dietary PUFA determine the types of fatty acids that are incorporated into immune cell membranes. Consequently, the physiological properties of immune cells and their potential to produce communication molecules, such as eicosanoids, can be modulated. This thesis aims to describe the (interaction) effects of n-3 and n-6 PUFA after challenge with antigens of various nature, and thereby to identify PUFA requirements for optimal immune responses in chickens. Antibody responses to model antigens known to induce T helper-1 and T helper-2 type responses in mice were increased or decreased by n-6, and increased or not affected by n-3 PUFA, depending on the antigen, and levels of other PUFA. Cutaneous hypersensitivity, an index for in vivo T cell reactivity, was increased by n-3 and decreased by n-6 PUFA or not affected. In vitro T cell reactivity was increased in chickens fed n-3 PUFA enriched diet. Evidence that vitamin E interacts with PUFA effects on immune cell function, particularly at high PUFA levels, was not found. Cytokine mRNA levels early after LPS challenge were increased by long-chain n-3 PUFA or not affected by dietary PUFA. The present thesis indicates that dietary PUFA have the potential to modulate chicken immune cell function, but that most effects are the contrary of what is usually found in mammals. The differences are possibly due to differences in chickens and mammals with regard to the metabolism and effector functions of PGE 2 , and the effects of dietary n-3 on cytokine production. It is hypothesized that inclusion of 1-2 % of n-3 and inclusion of no more than 3-4 % of n-6 in the diet, is optimal for Ab responsiveness, enhances T cell reactivity, and possibly improves chicken's disease

There are no comments yet. You can post the first one!
Post a comment
Please log in to use this service. Login as Wageningen University & Research user or guest user in upper right hand corner of this page.