Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 328048
Title Function and mode of regulation of the transcriptional acivator XlnR from Aspergillus
Author(s) Hasper, A.A.
Source Wageningen University. Promotor(en): A.J.J. van Ooyen, co-promotor(en): Leo de Graaff. - [S.l.] : S.n. - ISBN 9789058089212 - 137
Department(s) Microbiology
VLAG
Publication type Dissertation, internally prepared
Publication year 2004
Keyword(s) aspergillus niger - emericella nidulans - genetische modificatie - regulator-genen - transcriptiefactoren - aspergillus niger - emericella nidulans - genetic engineering - regulatory genes - transcription factors
Categories Microbiology (General) / Molecular Genetics
Abstract In Aspergillusniger, the expression of genes encoding enzymes involved in the degradation of xylan and cellulose is controlled by the transcriptional regulator XlnR. Besides controlling the expression of extracellular enzymes, XlnR was shown to regulate the transcription of genes encoding intracellular enzymes as D-xylose reductase. Also the transcription of a new endoglucanase that shows major activity towards xyloglucan is controlled by XlnR. It appears that XlnR plays an extensive role in the synergistic degradation of plant cell wall polysaccharides. Transcriptional regulators as XlnR are wide spread in nature; recently XlnR orthologues have been isolated from other fungi like Aspergillus oryzae , Neurospora crassa and  Trichoderma reesei . Alignment of these XlnR-like showed that several regions in the XlnR protein are highly conserved, among which the C-terminus. In A.nigerthis region was shown to fulfil a major regulatory role by controlling the activation or inactivation of XlnR.
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