Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 334006
Title Engineering metabolic highways in Lactococci and other lactic acid bacteria
Author(s) Vos, W.M. de; Hugenholtz, J.
Source Trends in Biotechnology 22 (2004)2. - ISSN 0167-7799 - p. 72 - 79.
DOI https://doi.org/10.1016/j.tibtech.2003.11.011
Department(s) Microbiology
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2004
Keyword(s) controlled gene-expression - complete genome sequence - exopolysaccharide production - lactate-dehydrogenase - sugar catabolism - streptococcus-thermophilus - molecular characterization - functional-analysis - diacetyl production - zymomonas-mobilis
Abstract Lactic acid bacteria (LAB) are widely used in industrial food fermentations and are receiving increased attention for use as cell factories for the production of food and pharmaceutical products. Glycolytic conversion of sugars into lactic acid is the main metabolic highway in these Gram-positive bacteria and Lactococcus lactis has become the model organism because of its small genome, genetic accessibility and simple metabolism. Here we discuss the metabolic engineering of L. lactis and the value of metabolic models compared with other LAB, with a particular focus on the food-grade production of metabolites involved in flavour, texture and health.
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