Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 338729
Title Functional ingredient production: application of global metabolic models
Author(s) Smid, E.J.; Molenaar, D.; Hugenholtz, J.; Vos, W.M. de; Teusink, B.
Source Current Opinion in Biotechnology 16 (2005)2. - ISSN 0958-1669 - p. 190 - 197.
DOI https://doi.org/10.1016/j.copbio.2005.03.001
Department(s) Microbiology
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2005
Keyword(s) lactic-acid bacteria - escherichia-coli - corynebacterium-glutamicum - saccharomyces-cerevisiae - lactococcus-lactis - industrial-production - pathway analysis - glycolysis - kinetics - networks
Abstract The biotechnology industry continuously explores new ways to improve the performance of microbial strains in fermentation processes. Recent focus has been on new genome-wide modelling approaches in functional genomics, which aim to take full advantage of genome sequence data, transcription profiling, proteomics and metabolite profiling for strain improvement. The integration of global metabolic models with genetic and regulatory models will be essential for the practice of metabolic engineering for strain improvement to move forward, simply because we cannot rely on our intuition to grasp the complexity of the biological systems involved
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