Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 342276
Title GeneSeeker: extraction and integration of human disease-related information from web-based genetic databases
Author(s) Driel, M.A. van; Cuelenaere, K.; Kemmeren, P.P.C.W.; Leunissen, J.A.M.; Brunner, H.G.; Vriend, G.
Source Nucleic acids research 33 (2005)SUPP/2. - ISSN 0305-1048 - p. w758 - w761.
DOI https://doi.org/10.1093/nar/gki435
Department(s) Bioinformatics
EPS
Publication type Refereed Article in a scientific journal
Publication year 2005
Keyword(s) candidate genes - expression database - genome database - disorders - identification - malformations - knowledgebase - map
Abstract The identification of genes underlying human genetic disorders requires the combination of data related to cytogenetic localization, phenotypes and expression patterns, to generate a list of candidate genes. In the field of human genetics, it is normal to perform this combination analysis by hand. We report on GeneSeeker (http://www.cmbi.ru.nl/GeneSeeker/), a web server that gathers and combines data from a series of databases. All database searches are performed via the web interfaces provided with the original databases, guaranteeing that the most recent data are queried, and obviating data warehousing. GeneSeeker makes the same selection of candidate genes as the human geneticists would have performed, and thus reducing the time-consuming process to a few minutes. GeneSeeker is particularly well suited for syndromes in which the disease gene displays altered expression patterns in the affected tissue(s).
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