Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 342680
Title Effect of 3-year folic acid supplementation on hearing thresholds in men and women with age-related hearing loss
Author(s) Durga, J.; Anteunis, L.J.C.; Schouten, E.G.; Bots, M.L.; Kok, F.J.; Verhoef, P.
Event 4th Conference on Hyperhomocysteinemia, 2005-04-14/2005-04-16
Department(s) Chair Nutrition and Health over the Lifecourse
Chair Nutrition and Disease
Publication type Abstract in scientific journal or proceedings
Publication year 2005
Abstract Age-related hearing loss is one of the most prevalent chronic conditions affecting the elderly. Age accounts for 10% of the variation in age-related hearing loss, thus factors that vary with age may play an etiological role in agerelated hearing loss. Low levels of B vitamins have been associated with poor hearing and animal studies have shown that B vitamin deficiency leads to cochlear malformations. In this study we examine the effect of 3-year oral folic acid supplementation (0.8 mg/d) v placebo in a double blind randomized controlled trial. Pure-tone air conduction thresholds in 729 middle-aged and elderly men and postmenopausal women with bilateral sensorineural hearing loss were measured at baseline and after 3 years. At baseline, homocysteine, erythrocyte folate and vitamin B6 were not associated with hearing thresholds, whereas, low concentrations of serum folate and vitamin B12 were associated with better hearing. The effect of folic acid supplementation has not yet been analyzed, but will be completed by the end of February 2005.
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