Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 342870
Title Meat and fish consumption, APC gene mutations and hMLH1 expression in colon and rectal cancer: a prospective cohort study (the Netherlands)
Author(s) Luchtenborg, M.; Weijenberg, M.P.; Goeij, A.F.P.M. de; Wark, P.A.; Brink, M.; Roemen, G.M.J.M.; Lentjes, M.H.F.M.; Bruine, A.P. de; Goldbohm, R.A.; Veer, P. van 't; Brandt, P.A. van den
Source Cancer Causes and Control 16 (2005)9. - ISSN 0957-5243 - p. 1041 - 1054.
Department(s) Nutrition and Disease
Department of Plant Sciences
Publication type Refereed Article in a scientific journal
Publication year 2005
Keyword(s) scale prospective cohort - colorectal-cancer - sporadic colon - microsatellite instability - adenomatous polyposis - k-ras - dietary factors - cluster region - carcinomas - tumors
Abstract Objective:The aim of this study was to investigate the associations between meat and fish consumption and APC mutation status and hMLH1 expression in colon and rectal cancer. Methods:The associations were investigated in the Netherlands Cohort Study, and included 434 colon and 154 rectal cancer patients on whom case-cohort analyses (subcohort n = 2948) were performed. Results:Total meat consumption was not associated with the endpoints studied. Meat product (i.e. processed meat) consumption showed a positive association with colon tumours harbouring a truncating APC mutation, whereas beef consumption was associated with an increased risk of colon tumours without a truncating APC mutation (incidence rate ratio (RR) highest versus lowest quartile of intake 1.61, 95% confidence interval (CI) 0.96¿2.71, p-trend = 0.04 and 1.58, 95% CI 1.10¿2.25, p-trend = 0.01, respectively). Consumption of other meat (horsemeat, lamb, mutton, frankfurters and deep-fried meat rolls) was associated with an increased risk of rectal cancer without a truncating APC mutation (RR intake versus no intake 1.79, 95% CI 1.10¿2.90). No associations were observed for meat consumption and tumours lacking hMLH1 expression. Conclusions:Our data indicate that several types of meat may contribute differently to the aetiology of colon and rectal cancer, depending on APC mutation status but not hMLH1 expression of the tumour.
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