Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 346577
Title Automatic tuning and adaptation for specific growth rate control of fed-batch cultivation
Author(s) Soons, Z.I.T.A.; Straten, G. van; Boxtel, A.J.B. van
Event Chemical Process Control 7, 2006-01-09/2006-01-13
Department(s) Systems and Control Group
VLAG
Publication type Contribution in proceedings
Publication year 2006
Abstract To ensure consistency between fed-batch cultivations for the production of vaccines or other bio-pharmaceuticals it is desirable to control the specific growth rate to a pre-set constant value. This is a challenge because the dynamics of the process is considerably changing due to the increase in volume and biomass as cultivation proceeds. Standard adaptive control can overcome this, but requires online identification by perturbing the system. In this study, an adaptive controller is designed, that does not demand online identification. The coarse adjustment of the controller gains is based on mass balances, while the fine tuning is performed by a novel tuning device that exploits the dynamics of the estimated error in specific growth rate. The only required measurement is the oxygen uptake rate. The controller and automatic tuning device are verified in simulation, and put to a test in laboratory experiments with Bordetella pertussis.
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