Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 347197
Title Remifentanil in the intensive care unit: tolerance and acute withdrawal syndrome after prolonged
Author(s) Delvaux, B.; Ryckwaert, Y.; Boven, R.M. van; Kock, M.; Capdevila, X.
Source Anesthesiology 102 (2005)6. - ISSN 0003-3022 - p. 1281 - 1282.
Department(s) ASG Infectieziekten
Publication type Refereed Article in a scientific journal
Publication year 2005
Keyword(s) analgesia-based sedation - critically-ill patients - continuous-infusion - daily interruption - fentanyl - adult - addiction - children
Abstract SEDATION in the intensive care unit should be minimized to reduce the duration of mechanical ventilation and its related complications.1 The drug regimen would ideally allow rapid awakening, to perform neurologic and respiratory evaluation on a daily basis.2,3 In this context, remifentanil, with its unique pharmacokinetic profile, should be considered an agent of choice.4,5 However, acute tolerance and even hyperalgesic response have been observed after opioid administration.6-8 In addition, withdrawal syndrome after cessation of opioid-based sedation has been seen in the intensive care unit setting.9-11 We report three cases of severe and fast-onset withdrawal syndrome, with signs of acute tolerance, after remifentanil-based sedation of between 2 and 30 days' duration, requiring reintroduction of remifentanil and then tapering over 24-48 h
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