Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 349531
Title Vaccines for viral and parasitic diseases produced with baculovirus vectors
Author(s) Oers, M.M. van
Source Advances in Virus Research 68 (2006). - ISSN 0065-3527 - p. 193 - 253.
Department(s) Laboratory of Virology
Publication type Refereed Article in a scientific journal
Publication year 2006
Keyword(s) virus-like particles - respiratory syncytial virus - infectious bursal disease - swine-fever virus - nuclear polyhedrosis-virus - influenza-a virus - merozoite surface protein-1 - chimeric fg glycoprotein - parvovirus empty capsids - hemagglutinin-neuraminidase gl
Abstract The baculovirus¿insect cell expression system is an approved system for the production of viral antigens with vaccine potential for humans and animals and has been used for production of subunit vaccines against parasitic diseases as well. Many candidate subunit vaccines have been expressed in this system and immunization commonly led to protective immunity against pathogen challenge. The first vaccines produced in insect cells for animal use are now on the market. This chapter deals with the tailoring of the baculovirus¿insect cell expression system for vaccine production in terms of expression levels, integrity and immunogenicity of recombinant proteins, and baculovirus genome stability. Various expression strategies are discussed including chimeric, viruslike particles, baculovirus display of foreign antigens on budded virions or in occlusion bodies, and specialized baculovirus vectors with mammalian promoters that express the antigen in the immunized individual. A historical overview shows the wide variety of viral (glyco)proteins that have successfully been expressed in this system for vaccine purposes. The potential of this expression system for antiparasite vaccines is illustrated. The combination of subunit vaccines and marker tests, both based on antigens expressed in insect cells, provides a powerful tool to combat disease and to monitor infectious agents.
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