Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 351445
Title Stress response and virulence in Salmonella Typhimurium: a genomics approach
Author(s) Hermans, A.P.H.M.
Source Wageningen University. Promotor(en): Tjakko Abee; Marcel Zwietering, co-promotor(en): H.J.M. Aarts. - [S.l.] : S.n. - ISBN 9789085045724 - 180
Department(s) Food Microbiology
RIKILT - Business Unit Safety & Health
Publication type Dissertation, internally prepared
Publication year 2007
Keyword(s) salmonella typhimurium - stressreactie - virulentie - bacteriofagen - transcriptie - genexpressieanalyse - salmonella typhimurium - stress response - virulence - bacteriophages - transcription - genomics
Categories Microbial Diversity
Abstract Since 1995 the number of human infections with Salmonella serovar Typhimurium DT104 increased in The Netherlands and abroad. The multi antibiotic resistance of this strain has been often proposed as plausible reason for this increase. Within his PhD research, Armand Hermans found novel DT104 specific DNA, that is most likely involved in virulence and might be an additional reason for the DT104 increase. In addition, the possibility for DT104 to survive certain process- and product conditions has been studied in this genomics based research. A better survival of stress such as acid or heat treatment could be another additional explanation for the DT104 increase. To enlarge the current insights on this topic, the activities of stress survival and virulence genes were studied by using the microarray technology. During exposure of DT104 to different stresses, similar stress survival mechanisms were activated, while different virulence mechanisms were stress specific activated. Bacterial cell communication also may play a role in regulation of these genes.
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