Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 354675
Title Fungal Biotransormation Products of Dehydroabietic Acid
Author(s) Beek, T.A. van; Claassen, F.W.; Dorado, J.; Godejohann, M.; Sierra-Alvarez, R.; Wijnberg, J.B.P.A.
Source Journal of Natural Products 70 (2007)2. - ISSN 0163-3864 - p. 154 - 159.
Department(s) Organic Chemistry
Publication type Refereed Article in a scientific journal
Publication year 2007
Keyword(s) pseudomonas-abietaniphila bkme-9 - mill effluent - kraft pulp - mortierella-isabellina - bacterial degradation - resin acids - paper-mill - hydroxylation - diterpenoids - constituents
Abstract Dehydroabietic acid (DHA) (1) is one of the main compounds in Scots pine wood responsible for aquatic and microbial toxicity. The degradation of 1 by Trametes versicolor and Phlebiopsis gigantea in liquid stationary cultures was followed by HPLC-DAD-ELSD. Both fungi rapidly degraded DHA relative to a control. More breakdown products were observed for T. versicolor than for P. gigantea. After 13 days, four compounds were identified by means of spectroscopic methods in P. gigantea cultures: 1 beta-hydroxy-DHA (2), 1 beta,7 alpha-dihydroxy-DHA (3), 1 beta,16-dihydroxy-DHA (5), and tentatively 1 beta-hydroxy-7-oxo-DHA (4). In T. versicolor cultures, 1 beta,16-dihydroxy-DHA (5), 7 beta,16-dihydroxy-DHA (6), 1 beta,7 beta,16-trihydroxy-DHA (7), 1 beta,16-dihydroxy-7-oxo-DHA (8), 1 beta,15-dihydroxy-DHA (9), and 1 beta,7 alpha,16-trihydroxy-DHA (10) were identified after 9 days of incubation. Thus the biotransformation of 1 by the two fungi was different, with only 5 being produced by both strains. Compounds 3, 7, 8, and 10 are reported for the first time as natural products.
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