Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 357092
Title Improvement and development of QSAR's for phenols
Author(s) Strikwold, M.; Zvinavashe, E.
Source Chemico-Biological Interactions 169 (2007)2. - ISSN 0009-2797 - p. 141 - 141.
Department(s) Toxicology
Publication type Abstract in scientific journal or proceedings
Publication year 2007
Abstract Quantitative Structure Activity Relationships (QSARs) are developed to predict a certain effect or property of a substance based on its chemical structure. Using QSARs is one alternative to animal testing. For instance, it can be used to indicate potential risks in the effect assessment of a chemical. At present, QSARs are available for quite a number of substances and different software tools are available to assist risk assessors in toxicological effect assessment. However, validation of these QSARs is limited. To apply QSARs more frequently, as desired by the European Commission, the availability of validated QSARs is required. For this purpose, in the year 2004 the OECD formulated and agreed on principles for the validation for regulatory purposes of QSAR models. The next step is to implement these principles to enhance the use of QSARs in evaluating substances. The present investigation will contribute to this by evaluating existing human and ecological QSARs of phenols and if possible to improve or develop new QSARs in accordance to OECD principles.
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