Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 357597
Title Dietary flavonoids and iodine Metabolism
Author(s) Elst, J.P. van der; Smit, J.W.A.; Romijn, H.A.; Heide, D. van der
Source BioFactors 19 (2003)3/4. - ISSN 0951-6433 - p. 171 - 176.
Department(s) Human and Animal Physiology
Publication type Refereed Article in a scientific journal
Publication year 2003
Keyword(s) human thyroid-carcinoma - cystic-fibrosis - symporter hnis - in-vitro - transporter - expression - cancer - epithelium - cloning - growth
Abstract Flavonoids have inhibiting effects on the proliferation of cancer cells, including thyroidal ones. In the treatment of thyroid cancer the uptake of iodide is essential. Flavonoids are known to interfere with iodide organification ill vitro, and to cause goiter. The influence of flavonoids on iodine metabolism was studied in a human thyroid cancer cell line (FTC-133) transfected with the human sodium/iodide transporter (NIS). All flavonoids inhibited growth, and iodide uptake was decreased in most cells. NIS mRNA expression was affected during the early hours after treatment, indicating that these flavonoids can act on NIS. Pendrin mRNA expression did not change after treatment. Only myricetin increased iodide uptake. Apeginin, luteolin, kaempferol and F21388 increased the efflux of iodide, leading to a decreased retention of iodide. Instead myricetin increased the retention of iodide; this could be of use in the radioiodide treatment of thyroid cancer.
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