Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 358634
Title Response to LPS in female offspring from sows treated with cortisol during pregnancy
Author(s) Groot, J. de; Kranendonk, G.; Fillerup, M.; Hopster, H.; Boersma, W.; Hodgson, D.; Reenen, K. van; Taverne, M.
Source Physiology and Behavior 90 (2007)4. - ISSN 0031-9384 - p. 612 - 618.
Department(s) Adaptation Physiology
ID - Dier en Omgeving
Wageningen Livestock Research
CVI - Division Virology
Publication type Refereed Article in a scientific journal
Publication year 2007
Keyword(s) pituitary-adrenal axis - messenger-rna expression - prenatal stress - 11-beta-hydroxysteroid dehydrogenase - behavior - glucocorticoids - pigs - gestation - gilts - rat
Abstract Prenatal stress has been shown to program responsiveness of the hypothalamus¿pituitary¿adrenal axis (HPA-axis) and behavior in offspring. In pig husbandry, sows are exposed to stressful conditions during gestation. Previously, cortisol treatment of pregnant sows has been shown to alter stress responsiveness and immunological parameters in their piglets. In the present study, we explored whether cortisol treatment of pregnant sows affects the offspring's response to an inflammatory stimulus. Sows were treated orally with cortisol either during the first, second, or third period of gestation, or received a placebo during this period. At 8 weeks of age, female offspring were injected intravenously with lipopolysaccharide (LPS). Offspring of sows that received cortisol during the first and third period of gestation showed a higher fever response to LPS. Cortisol treatment of sows during gestation did not affect offspring's response to LPS with regard to their cortisol response. LPS-induced sickness behavior, which was measured as the latency time in a human approach test, appeared to recover more quickly in offspring from sows that received cortisol during the second period of gestation. These results suggest that prenatal cortisol exposure programs responsiveness to inflammatory stimuli in female piglets.
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