Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 358641
Title Body Fat Deposition Does Not Originate from Carbohydrates in Milk-Fed Calves
Author(s) Borne, J.J.G.C. van den; Lobley, G.E.; Verstegen, M.W.A.; Muylaert, J.M.; Alferink, S.J.J.; Gerrits, W.J.J.
Source The Journal of Nutrition 137 (2007)10. - ISSN 0022-3166 - p. 2234 - 2241.
DOI https://doi.org/10.1093/jn/137.10.2234
Department(s) Animal Nutrition
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2007
Keyword(s) breath test measurements - essential amino-acids - whole-body - urea kinetics - intestinal metabolism - substrate oxidation - preruminant calves - growing pigs - protein - leucine
Abstract Milk-fed heavy calves utilize dietary protein with a low efficiency and often develop hyperglycemia and insulin resistance. Distributing the daily nutrient intake over an increasing number of meals increases protein deposition and improves glucose homeostasis. Therefore, we examined effects of feeding frequency (FF) and feeding level (FL) on the diurnal pattern of substrate oxidation and on the fate of dietary carbohydrates in milk-fed heavy calves. Eighteen milk-fed calves weighing 136 ± 3 kg were assigned to FF (1, 2, or 4 meals daily) at each of 2 FL (1.5 or 2.5 times maintenance), except for calves at FF1 (only at a low FL). Urea, leucine, and glucose kinetics were assessed for each treatment by use of [13C]urea, [1-13C]leucine, [U-13C], and [2-13C]glucose, respectively. FF altered the diurnal pattern, but not the total, of urea production production. Although urea production correlated well with nitrogen retention, oxidation of oral L-[1-13C]leucine did not. Dietary glucose was almost completely oxidized (80% based on [13C]glucose and 94% from indirect calorimetry measurements) regardless of FL. Fatty acid synthesis from glucose appeared to be negligible based on similar recoveries of 13CO2 from orally supplied [U-13C]glucose and [2-13C]glucose. The increased fat deposition at the higher FL originated almost exclusively from greater transfer of fatty acids to body lipid stores. These findings contrast with both glucose and lipid metabolism in growing pigs and indicate that alternative adaptive mechanisms operate in heavy milk-fed calves.
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