Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 359270
Title Improvement of lipoxygenase inhibition by octapeptides
Author(s) Schurink, M.; Berkel, W.J.H. van; Wichers, H.J.; Boeriu, C.G.
Source Peptides 28 (2007)12. - ISSN 0196-9781 - p. 2268 - 2275.
DOI https://doi.org/10.1016/j.peptides.2007.09.018
Department(s) Biochemistry
Cell Biology and Immunology
AFSG Food Quality
AFSG Biobased Products
VLAG
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2007
Keyword(s) spot-synthesis - soybean lipoxygenase-1 - cancer - expression - peptides - quality
Abstract The ß-casein-derived octapeptide RINKKIEK is a noncompetitive inhibitor of soybean lipoxygenase (LOX). To investigate the molecular determinants for the enzyme¿peptide interaction, a peptide library containing substitutional analogs of RINKKIEK was prepared by SPOT synthesis and analyzed for interaction with fluorescent-labeled LOX. The positively charged amino acid residues in RINKKIEK appear to be essential for the LOX¿peptide interaction. Replacement of the negatively charged glutamic acid by any other amino acid residue improves LOX binding. For both RINKKIPK and RINKKISK this increase in LOX binding is accompanied by a threefold increase in LOX inhibition.
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