Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 359494
Title Structural and functional analysis of Eukaryal-like proteins from the hyperthermophilic archaeon Sulfolobus solfataricus
Author(s) Wu Hao,
Source Wageningen University. Promotor(en): John van der Oost; Willem de Vos, co-promotor(en): Z. Rao. - [S.l.] : S.n. - ISBN 9789085048220 - 150
Department(s) VLAG
Publication type Dissertation, internally prepared
Publication year 2007
Keyword(s) eiwitten - moleculaire structuur - eiwitgebruik - alfa-galactosidase - archaea - proteins - molecular conformation - protein utilization - alpha-galactosidase - archaea
Categories Microbiology (General) / Proteins and Enzymes
Abstract The research presented in this thesis is aimed at applying technologies in bioinformatics, biochemistry, structural biology and cell biology to reveal the global regulation network in archaea, gain insights in the mechanism of archaeal signal transduction, and provide details on the evolution of the well-conserved archaeal-eukaryal information processing systems (i.e. transcription, translation, and replication). The global regulation network includes several novel core eukaryal-like proteins (e.g. MBF and SsGBP) that are predicted to operate in the regulation of transcription and/or translation in archaea. In addition, approaches are described to analyze the function of the predicted regulators that involved the development of antibiotic resistance marker for hyperthermophiles since the genetic modification of hyperthermophiles has been hampered, at least in part, by the lack of suitable selection markers.
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