Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 359511
Title Dietary intake of B6-9-12 vitamins, serum homocysteine levels and their association with depressive symptoms: the Zutphen Elderly Study
Author(s) Kamphuis, M.H.; Geerlings, M.I.; Grobbee, D.E.; Kromhout, D.
Source European Journal of Clinical Nutrition 62 (2008). - ISSN 0954-3007 - p. 939 - 945.
Department(s) Nutrition and Disease
Publication type Refereed Article in a scientific journal
Publication year 2008
Keyword(s) cognitive function - myocardial-infarction - community sample - dutch population - older women - folic-acid - follow-up - folate - men - scale
Abstract Objective: Low B-vitamin status and high levels of serum homocysteine are found in depressed inpatients, but results of population-based studies of this association are inconclusive. We investigated whether a low dietary intake of B6-9-12 vitamins and high levels of serum homocysteine are associated with depressive symptoms in elderly men. Methods: The study sample included a total of 332 men aged 70¿90 years who were free from cardiovascular diseases and diabetes at baseline in 1990. Depressive symptoms were measured with the Zung Self-rating Depression Scale at baseline in 1990 and dietary factors with the crosscheck dietary history method in 1985 and 1990. Serum levels of homocysteine were obtained in 1985. Multiple linear and logistic regression analyses were performed. Results: Dietary intake of folate (-1.19, 95% CI -2.03; -0.36) and vitamin B6 (-2.09, 95% CI -2.92; -1.26) per standard deviation increase was associated with lower levels of serum homocysteine, while vitamin B12 was not associated with serum homocysteine. Intake of folate, vitamin B6, vitamin B12 and levels of serum homocysteine were not related to depressive symptoms. Conclusions: Our results do not support the hypothesis that a low dietary intake of B6-9-12 vitamins and high levels of serum homocysteine are related to depression in healthy elderly men.
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