Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 362511
Title Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88
Author(s) Pel, H.J.; Winde, J.H. de; Archer, D.B.; Schaap, P.J.; Benen, J.A.E.; Debets, A.J.M.; Kools, H.J.; Pal, K.
Source Nature Biotechnology 25 (2007). - ISSN 1087-0156 - p. 221 - 231.
DOI https://doi.org/10.1038/nbt1282
Department(s) Microbiology
Laboratory of Genetics
VLAG
PE&RC
Publication type Refereed Article in a scientific journal
Publication year 2007
Keyword(s) unfolded protein response - saccharomyces-cerevisiae - filamentous fungi - fumigatus - nidulans - dna - reconstruction - degradation - metabolism - autolysis
Abstract The filamentous fungus Aspergillus niger is widely exploited by the fermentation industry for the production of enzymes and organic acids, particularly citric acid. We sequenced the 33.9-megabase genome of A. niger CBS 513.88, the ancestor of currently used enzyme production strains. A high level of synteny was observed with other aspergilli sequenced. Strong function predictions were made for 6,506 of the 14,165 open reading frames identified. A detailed description of the components of the protein secretion pathway was made and striking differences in the hydrolytic enzyme spectra of aspergilli were observed. A reconstructed metabolic network comprising 1,069 unique reactions illustrates the versatile metabolism of A. niger. Noteworthy is the large number of major facilitator superfamily transporters and fungal zinc binuclear cluster transcription factors, and the presence of putative gene clusters for fumonisin and ochratoxin A synthesis.
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