Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 365003
Title Bayesian estimation of hepatitis E virus seroprevalence for populations with different exposure levels to swine in The Netherlands
Author(s) Bouwknegt, M.; Engel, B.; Herremans, M.M.P.T.; Widdowson, M.A.; Worm, H.C.; Koopmans, M.P.G.; Frankena, K.; Roda Husman, A.M. de; Jong, M.C.M. de; Poel, W.H.M. van der
Source Epidemiology and Infection 136 (2008)4. - ISSN 0950-2688 - p. 567 - 576.
Department(s) Quantitative Veterinary Epidemiology
ASG Infectieziekten
Publication type Refereed Article in a scientific journal
Publication year 2008
Keyword(s) diagnostic-tests - disease prevalence - gold standard - antibody - veterinarians - specificity - sensitivity - infection - absence - deer
Abstract Hepatitis E virus (HEV) is ubiquitous in pigs worldwide and may be zoonotic. Previous HEV seroprevalence estimates for groups of people working with swine were higher than for control groups. However, discordance among results of anti-HEV assays means that true seroprevalence estimates, i.e. seroprevalence due to previous exposure to HEV, depends on choice of seroassay. We tested blood samples from three subpopulations (49 swine veterinarians, 153 non-swine veterinarians and 644 randomly selected individuals from the general population) with one IgM and two IgG ELISAs, and subsets with IgG and/or IgM Western blots. A Bayesian stochastical model was used to combine results of all assays. The model accounted for imperfection of each assay by estimating sensitivity and specificity, and accounted for dependence between serological assays. As expected, discordance among assay results occurred. Applying the model yielded seroprevalence estimates of ~11% for swine veterinarians, ~6% for non-swine veterinarians and ~2% for the general population. By combining the results of five serological assays in a Bayesian stochastical model we confirmed that exposure to swine or their environment was associated with elevated HEV seroprevalence.
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