Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 366670
Title In vitro and in vivo virulence of Salmonella Typhimurium DT104: a parallelogram approach
Author(s) Berk, P.A.
Source Wageningen University. Promotor(en): Tjakko Abee; Marcel Zwietering, co-promotor(en): R. Jonge. - [S.l. : S.n. - ISBN 9789085049340 - 167
Department(s) Food Microbiology
VLAG
Publication type Dissertation, externally prepared
Publication year 2008
Keyword(s) salmonella typhimurium - virulentie - zuren - weerstand - stressreactie - antibioticaresistentie - salmonella typhimurium - virulence - acids - resistance - stress response - antibiotic resistance
Categories Food Microbiology
Abstract Salmonella is present in different food products. In this research it is concluded that Salmonella, which can survive the stomach of humans better (acid resistant bacteria), have a higher probability of causing an infection than Salmonella strains that are less able to survive the stomach (acid sensitive bacteria). The probability of such an infection is determined using different model systems. Effects on an infection with cultured human and rat intestinal cells were comparable to results obtained with a rat model. The probability of infection calculated with the results from both model systems agree with data from human experiments conducted in the fifties and with epidemiological dose response data. If these results can be founded by additional research, with different Salmonella species, it could be possible to reduce the amount of animal experiments in the future.
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