Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 369590
Title Towards a Neisseria meningitidis B vaccine : introducing systems biology in process development
Author(s) Baart, G.J.E.
Source Wageningen University. Promotor(en): Hans Tramper, co-promotor(en): Dirk Martens; E.C. Beuvery. - [S.l.] : S.n. - ISBN 9789085049975 - 276
Department(s) Bioprocess Engineering
VLAG
Publication type Dissertation, internally prepared
Publication year 2008
Keyword(s) neisseria meningitidis - vaccinontwikkeling - wiskundige modellen - celmetabolisme - modelleren - bioproceskunde - neisseria meningitidis - vaccine development - mathematical models - cell metabolism - modeling - bioprocess engineering
Categories Biological Operations
Abstract
Towards a Neisseria meningitidis B vaccine
Neisseria meningitidis is a bacterium that is only found in humans and can cause the diseases meningitis or septicaemia, especially in young children. At the Netherlands Vaccine Institute a vaccine against serogroup B meningococci, which causes about 50% of the disease cases worldwide, is currently being developed. The pathogen itself is the basis of the vaccine. To obtain more insight in the metabolism of meningococci, a mathematical model of metabolism was constructed, using its genome sequence as a starting point and the validity of this metabolic model was checked under different experimental conditions. The gathered knowledge was used to design a synthetic medium for growth of serogroup B meningococci and for the development of a cultivation process. In addition, the research has led to the realization of equipment in which bulk production of serogroup B meningococci is possible, which brings a publically available vaccine a step closer.



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