Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 370571
Title Experimental challenge models for Johne's disease: a review and proposed international guidelines
Author(s) Hines, M.E.; Stabel, J.R.; Sweeney, R.W.; Griffin, F.; Talaat, A.M.; Bakker, D.; Benedictus, G.; Davis, W.C.; Lisle, G.W. de; Gardner, I.A.; Juste, R.A.; Kapur, V.; Koets, A.; McNair, J.; Pruitt, G.; Whitlock, R.H.
Source Veterinary Microbiology 122 (2007)39541. - ISSN 0378-1135 - p. 197 - 222.
Department(s) CVI - Divisie Bacteriologie en TSE's
Publication type Refereed Article in a scientific journal
Publication year 2007
Keyword(s) avium subsp paratuberculosis - swiss white mice - deer cervus-elaphus - experimental para-tuberculosis - experimental-infection model - experimental oral infection - linked-immunosorbent-assay - american wild ruminants - small-intestinal mucosa - mycobacterium-avi
Abstract An international committee of Johne's disease (JD) researchers was convened to develop guidelines for JD challenge studies in multiple animal species. The intent was to develop and propose international standard guidelines for models based on animal species that would gain acceptance worldwide. Parameters essential for the development of long-term and short-term infection models were outlined and harmonized to provide a ¿best fit¿ JD challenge model for cattle, goats, sheep, cervids, and mice. These models will be useful to study host¿pathogen interactions, host immunity at the local and systemic level, and for evaluating vaccine candidates and therapeutics. The consensus guidelines herein list by animal species strains of Mycobacterium avium subsp. paratuberculosis used, challenge dose, dose frequency, age of challenge, route of challenge, preparation of inoculum, experimental animal selection, quality control, minimal experimental endpoints and other parameters.
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