Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 372151
Title Neonatal diarrhoea in pigs: alpha- and beta(2)-toxin produced by Clostridium perfringens
Author(s) Hendriksen, S.W.M.; Leengoed, L.A.M.G. van; Roest, H.I.J.; Nes, A. van
Source Tijdschrift voor Diergeneeskunde 131 (2006)24. - ISSN 0040-7453 - p. 910 - 913.
Department(s) CIDC - Divisie Bacteriologie en TSE's
Publication type Refereed Article in a scientific journal
Publication year 2006
Keyword(s) varkenshouderij - clostridium perfringens - diergeneeskunde - diarree - biggenziekten - toxinen - vaccinatie - vaccinontwikkeling - autovaccins - diagnostische technieken - diagnose - pig farming - clostridium perfringens - veterinary science - diarrhoea - piglet diseases - toxins - vaccination - vaccine development - autogenous vaccines - diagnostic techniques - diagnosis - beta2 toxin - animals - prevalence - piglets - gene
Categories Veterinary Science (General)
Abstract Since 2001 the Pig Health Unit of Utrecht University has been consulted by various pig farms regarding neonatal diarrhoea. When preventive measures against E. coli-induced diarrhoea had no or limited results, the diarrhoeic piglets were investigated further. The microbiological and pathological findings were indicative of infection with Clostridium perfringens. Toxin typing by polymerase chain reaction led to the detection of genes encoding a-toxin (cpa) and beta2-toxin (cpb2). Surprisingly, alpha- and beta2-toxin-producing C. perfringens was isolated from all tested herds with piglets with neonatal diarrhoea. From our observations, it is likely that many herds in the Netherlands are infected with beta2-toxin-producing C. perfringens strains. As present vaccines lack beta2-toxoid and thus do not provide piglets with protection against beta2-induced diarrhoea.
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