Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 388210
Title Respiratory function and other biological risk factors for completed suicide: 40 years of follow-up of European cohorts of the Seven Countries Study
Author(s) Giltay, E.J.; Zitman, F.G.; Menotti, A.; Nissinen, A.; Jacobs, D.R.; Adachi, H.; Kafatos, A.; Kromhout, D.
Source Journal of Affective Disorders 120 (2010)1-3. - ISSN 0165-0327 - p. 249 - 253.
Department(s) Nutrition and Disease
Publication type Refereed Article in a scientific journal
Publication year 2010
Keyword(s) body-mass index - serum-cholesterol - united-states - lung-function - men - association - mortality - height - death - ideation
Abstract Background - Prospective cohort studies on biological risk factors of completed suicide are scarce. We aimed to test which biological risk factors independently identify subjects at increased risk of suicidal death. Methods - In the prospective cohort of the Seven Countries Study, 5,321 middle-aged men from Finland, Serbia, Italy, and Greece were included. Completed suicide (ICD-8 codes E950-959) was assessed during 40 years of follow-up. Biological cardiovascular risk factors (including forced vital capacity [FVC] and height) were tested for their role as predictors in multivariable Cox models stratified by country. Results - There were 4518 deaths during follow-up, with 64 from suicide (1.4%). In univariable models, only FVC and height were strongly inversely related with suicide. Socio-economic status and being unmarried were potential confounders. In multivariable models taking these confounders into account, both a low FVC (0.30 for top vs. lowest quartile; 95% CI: 0.12–0.76; P = 0.006 for trend) and a low FVC/height ratio (0.37 for top vs. lowest quartile; 95% CI: 0.17–0.82; P = 0.004 for trend) were strongly inversely related with completed suicide. Limitations - Information on proximal causes, such as prior suicidal ideation, emotional distress and depression, was lacking at baseline. Conclusions - Poor respiratory function in middle-aged men was an independent risk factor for completed suicide
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