Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 396451
Title Global Genetic Robustness of the Alternative Splicing Machinery in Caenorhabditis elegans
Author(s) Li, Y.; Breitling, R.; Snoek, L.B.; Velde, K.J. van der; Swertz, M.A.; Riksen, J.A.G.; Jansen, R.C.; Kammenga, J.E.
Source Genetics 186 (2010). - ISSN 0016-6731 - p. 405 - 410.
Department(s) Laboratory of Nematology
PRI Biometris
Publication type Refereed Article in a scientific journal
Publication year 2010
Keyword(s) statistics
Abstract Alternative splicing is considered a major mechanism for creating multicellular diversity from a limited repertoire of genes. Here, we performed the first study of genetic variation controlling alternative splicing patterns by comprehensively identifying quantitative trait loci affecting the differential expression of transcript isoforms in a large recombinant inbred population of Caenorhabditis elegans, using a new generation of whole-genome very-high-density oligonucleotide microarrays. Using 60 experimental lines, we were able to detect 435 genes with substantial heritable variation, of which 36% were regulated at a distance (in trans). Nonetheless, we find only a very small number of examples of heritable variation in alternative splicing (22 transcripts), and most of these genes colocalize with the associated genomic loci. Our findings suggest that the regulatory mechanism of alternative splicing in C. elegans is robust toward genetic variation at the genome-wide scale, which is in striking contrast to earlier observations in humans.
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