Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 403665
Title Altered Host-Microbe Interaction in HIV: A Target for Intervention with Pro- and Prebiotics
Author(s) Hummelen, R.; Vos, A.P.; Land, B. van 't; Norren, K. van; Reid, G.
Source International Reviews of Immunology 29 (2010)5. - ISSN 0883-0185 - p. 485 - 513.
Department(s) Nutritional Biology and Health
Publication type Refereed Article in a scientific journal
Publication year 2010
Keyword(s) human-immunodeficiency-virus - randomized controlled-trial - placebo-controlled trial - coli nissle 1917 - chain galacto-oligosaccharides - active antiretroviral therapy - inflammatory bowel diseases - intestinal epithelial-cells - lactobacillus-rhamnosus-gg - ele
Abstract The intestinal immune system is severely affected by HIV and circulating microbial products from the intestinal tract that provide an ongoing source of systemic inflammation and concomitant viral replication. In addition, HIV-infected individuals can have a deregulated immune response that may hamper the anti-viral capacity of the host. Various probiotic organisms and prebiotic agents have been shown to enhance intestinal epithelial barrier functions, reduce inflammation, and support effective Th-1 responses. As these characteristics may benefit HIV patients, this review aims to provide a theoretical framework for the development of probiotic and prebiotic interventions specifically for this population.
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