Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 429193
Title Transitions in smoking behaviour and the design of cessation schemes.
Author(s) Grasman, J.; Grasman, R.P.P.P.; Maas, H.L.J. van der
Source PLoS ONE 7 (2012)10. - ISSN 1932-6203
Department(s) Mathematical and Statistical Methods - Biometris
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) nicotinic acetylcholine-receptors - quit smoking - tobacco use - withdrawal - addiction - cigarettes - abrupt
Abstract The intake of nicotine by smoking cigarettes is modelled by a dynamical system of differential equations. The variables are the internal level of nicotine and the level of craving. The model is based on the dynamics of neural receptors and the way they enhance craving. Lighting of a cigarette is parametrised by a time-dependent Poisson process. The nicotine intake rate is assumed to be proportional with the parameter of this stochastic process. The effect of craving is damped by a control mechanism in which awareness of the risks of smoking and societal measures play a role. Fluctuations in this damping may cause transitions from smoking to non-smoking and vice versa. With the use of Monte Carlo simulation the effect of abrupt and gradual cessation therapies are evaluated. Combination of the two in a mixed scheme yields a therapy with a duration that can be set at wish.
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