Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 432526
Title Chenodeoxycholic acid improves intestinal permeability in piglets
Author(s) Meer, Y. van der; Gerrits, W.J.J.; Bosch, M. van den; Holst, J.J.; Kulik, W.; Kempen, T.A.T.G. van
Source In: Digestive Physiology of Pigs, book of abstracts, Keystone, CO, USA, May 29 - June 1, 2012. - Keystone, Co, USA : - p. 107 - 107.
Event Keystone, Co, USA : XII International symposium on digestive physiology of pigs, Keystone, CO, USA, May 29 - June 1, 2012, 2012-05-29/2012-06-01
Department(s) Animal Nutrition
Publication type Abstract in scientific journal or proceedings
Publication year 2012
Abstract Piglets are highly susceptible to gut health-related problems. Intravenously administered chenodeoxycholic acid (CDCA) affects gut health mediated through GLP-2. To test if CDCA is a suitable feed additive for improving gut health, a trial was performed with newly weaned (21 d) piglets offered a diet with or without 60 mg CDCA/kg feed (n = 24/trt). Upon weaning piglets were fasted for 16 h and then intragastrically dosed with 20 g test feed in 40 g water. Subsequently, a jugular blood sample was taken on either 45, 90, 135, or 180 min for analysis of GLP-2, PYY, and glucose. Afterward, piglets were fed ad libitum. On d 3.5, 7.5, and 10.5 post weaning, 8 piglets per treatment were sacrificed for determination of in vivo intestinal permeability using lactulose and Co-EDTA. Both markers were administrated intragastrically and after 2h, a blood sample was obtained through venipuncture. Immediately thereafter, intestines were harvested, and ex vivo permeability was measured using the everted gut sac technique with 4 kDa FITC-dextran as marker at 25, 50, and 75% of the length of the small intestines. Average daily feed intake, daily gain, gain:feed, blood glucose, plasma GLP-2, and PYY were not affected by dietary CDCA (P > 0.10). Serum Co-EDTA and lactulose concentrations at d 10.5 tended to be lower in CDCA pigs compared with the control pigs (P = 0.054, P = 0.089). The everted gut sac technique data did not show any treatment effects on permeability (P > 0.10), possibly due to reaction of the FITC-marker with light despite covering with aluminum foil. In conclusion, CDCA tended to improve intestinal permeability at 10.5 d post weaning when fed to newly weaned piglets, implying that CDCA deserves further study as a means for improving intestinal health
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