Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 432736
Title The imprinted gene DIO3 is a candidate gene for litter size in pigs
Author(s) Coster, N.B.; Madsen, O.; Heuven, H.C.M.; Dibbits, B.W.; Groenen, M.A.M.; Arendonk, J.A.M. van; Bovenhuis, H.
Source PLoS ONE 7 (2012)2. - ISSN 1932-6203
Department(s) Animal Breeding and Genomics
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) quantitative trait loci - origin allelic expression - meat quality - genome scan - evolutionary conservation - swine chromosome-2 - type-3 deiodinase - mouse-brain - muscle mass - igf2 locus
Abstract Genomic imprinting is an important epigenetic phenomenon, which on the phenotypic level can be detected by the difference between the two heterozygote classes of a gene. Imprinted genes are important in both the development of the placenta and the embryo, and we hypothesized that imprinted genes might be involved in female fertility traits. We therefore performed an association study for imprinted genes related to female fertility traits in two commercial pig populations. For this purpose, 309 SNPs in fifteen evolutionary conserved imprinted regions were genotyped on 689 and 1050 pigs from the two pig populations. A single SNP association study was used to detect additive, dominant and imprinting effects related to four reproduction traits; total number of piglets born, the number of piglets born alive, the total weight of the piglets born and the total weight of the piglets born alive. Several SNPs showed significant () additive and dominant effects and one SNP showed a significant imprinting effect. The SNP with a significant imprinting effect is closely linked to DIO3, a gene involved in thyroid metabolism. The imprinting effect of this SNP explained approximately 1.6% of the phenotypic variance, which corresponded to approximately 15.5% of the additive genetic variance. In the other population, the imprinting effect of this QTL was not significant (), but had a similar effect as in the first population. The results of this study indicate a possible association between the imprinted gene DIO3 and female fertility traits in pigs.
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