Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 434553
Title Development of surface plasmon resonance-based sensor for detection of silver nanoparticles in food and the environment
Author(s) Rebe-Raz, S.; Leontaridou, M.; Bremer, M.G.E.G.; Peters, R.J.B.; Weigel, S.
Source Analytical and Bioanalytical Chemistry 403 (2012)10. - ISSN 1618-2642 - p. 2843 - 2850.
DOI https://doi.org/10.1007/s00216-012-5920-z
Department(s) Environmental Economics and Natural Resources
RIKILT - Business Unit Safety & Health
BU Contaminants & Toxins
BU Microbiological & Chemical Food Analysis
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) heavy-metals - metallothionein - immobilization - biosensor - ions - nanosilver - proteins
Abstract Silver nanoparticles are recognized as effective antimicrobial agents and have been implemented in various consumer products including washing machines, refrigerators, clothing, medical devices, and food packaging. Alongside the silver nanoparticles benefits, their novel properties have raised concerns about possible adverse effects on biological systems. To protect consumer’s health and the environment, efficient monitoring of silver nanoparticles needs to be established. Here, we present the development of human metallothionein (MT) based surface plasmon resonance (SPR) sensor for rapid detection of nanosilver. Incorporation of human metallothionein 1A to the sensor surface enables screening for potentially biologically active silver nanoparticles at parts per billion sensitivity. Other protein ligands were also tested for binding capacity of the nanosilver and were found to be inferior to the metallothionein. The biosensor has been characterized in terms of selectivity and sensitivity towards different types of silver nanoparticles and applied in measurements of real-life samples—such as fresh vegetables and river water. Our findings suggest that human MT1-based SPR sensor has the potential to be utilized as a routine screening method for silver nanoparticles, that can provide rapid and automated analysis dedicated to environmental and food safety monitoring.
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