Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 439650
Title Probiotics lactobacillus reuteri DSM 17938 and lactobacillus casei CRL 431 modestly increase growth, but non iron and zinc status, among Indonesian children aged 1-6 years
Author(s) Agustina, R.; Bovee-Oudenhoven, I.M.J.; Lukito, W.; Fahmida, U.; Rest, O. van de; Zimmermann, M.B.; Firmansyah, A.; Wulanti, R.; Albers, R.; Heuvel, E.G.H.M. van den; Kok, F.J.
Source The Journal of Nutrition 143 (2013)7. - ISSN 0022-3166 - p. 1184 - 1193.
Department(s) VLAG
Global Nutrition
Publication type Refereed Article in a scientific journal
Publication year 2013
Keyword(s) c-reactive protein - calcium supplementation - nonheme-iron - deficiency anemia - controlled-trial - dietary calcium - acute diarrhea - double-blind - cows milk - heme-iron
Abstract Probiotics and milk calcium may increase resistance to intestinal infection, but their effect on growth and iron and zinc status of Indonesian children is uncertain. We investigated the hypotheses that cow milk with added probiotics would improve growth and iron and zinc status of Indonesian children, whereas milk calcium alone would improve growth but reduce iron and zinc status. A 6-mo randomized trial was conducted in low-socioeconomic urban communities of Jakarta. Healthy children (n = 494) were randomly assigned to receive low-lactose milk with a low calcium content of similar to 50 mg/d (LC; n = 124), a regular calcium content of similar to 440 mg/d (RC group; n = 126), regular calcium with 5 x 10(8) CFU/d Lactobacillus casei CRL 431 (casei; n = 120), or regular calcium with 5 x 10(8) CFU/d Lactobacillus reuteri DSM 17938 (reuteri; n = 124). Growth, anemia, and iron and zinc status were assessed before and after the intervention. Compared with the RC group, the reuteri group had significantly greater weight gain [0.22 (95% CI: 0.02, 0.42) kg], weight-for-age Z-score (WAZ) changes [0.09 (95% CI: 0.01, 0.17)], and monthly weight [0.03(95% CI: 0.002, 0.05) kg/mo] and height [0.03(95% Cl: 0.01, 0.05) cm/mo] velocities. Casei significantly increased monthly weight velocity [0.03 (95% CI: 0.001, 0.05) kg/mo], but not height. However, the changes in underweight, stunting, anemia prevalence, and iron and zinc status were similar between groups. In conclusion, L. reuteri DSM 17938 modestly improved growth by increasing weight gain, WAZ changes, and weight and height velocity, whereas L. casei CRL 431 modestly improved weight velocity. Independent from probiotics supplementation, regular milk calcium did not affect growth or iron and zinc status.
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