Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 446055
Title Self-consistent field predictions for quenched spherical biocompatible triblock copolymer micelle
Author(s) Lebouille, J.G.J.L.; Tuinier, R.; Vleugels, L.F.W.; Cohen Stuart, M.A.; Leermakers, F.A.M.
Source Soft Matter 9 (2013)31. - ISSN 1744-683X - p. 7515 - 7525.
DOI https://doi.org/10.1039/c3sm27829h
Department(s) Physical Chemistry and Colloid Science
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2013
Keyword(s) interacting chain molecules - angle neutron-scattering - aqueous-solution - statistical-theory - block-copolymers - micellization - adsorption - biodegradation - microspheres - degradation
Abstract We have used the Scheutjens–Fleer self-consistent field (SF-SCF) method to predict the self-assembly of triblock copolymers with a solvophilic middle block and sufficiently long solvophobic outer blocks. We model copolymers consisting of polyethylene oxide (PEO) as the solvophilic block and poly(lactic-co-glycolic) acid (PLGA) or poly(e-caprolactone) (PCL) as the solvophobic block. These copolymers form structurally quenched spherical micelles provided the solvophilic block is long enough. Predictions are calibrated on experimental data for micelles composed of PCL-PEO-PCL and PLGA-PEO-PLGA triblock copolymers prepared via the nanoprecipitation method. We establish effective interaction parameters that enable us to predict various micelle properties such as the hydrodynamic size, the aggregation number and the loading capacity of the micelles for hydrophobic species that are consistent with experimental findings
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