Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 447881
Title Impact of oral vancomycin on gut microbiota, bile acid metabolism, and insulin sensitivity
Author(s) Vrieze, A.; Out, C.; Fuentes Enriquez de Salamanca, S.; Jonker, L.; Reuling, I.; Kootte, R.S.; Nood, E. van; Holleman, F.; Knaapen, M.; Romijn, J.A.; Soeters, M.R.; Blaak, E.E.; Dallinga-Thie, G.M.; Reijnders, D.; Ackermans, M.T.; Serlie, M.J.; Knop, F.K.; Holst, J.J.; Ley, C.V.; Kema, I.P.; Zoetendal, E.G.; Vos, W.M. de; Hoekstra, J.B.; Stroes, E.S.; Groen, A.K.; Nieuwdorp, M.
Source Journal of Hepatology 60 (2014)4. - ISSN 0168-8278 - p. 824 - 831.
Department(s) Host-Microbe Interactomics
Publication type Refereed Article in a scientific journal
Publication year 2014
Keyword(s) salt hydrolase activity - diet-induced obesity - intestinal microbiota - energy-expenditure - mice - resistance - adiposity - glucagon - capacity - humans
Abstract BACKGROUND: Obesity has been associated with changes in the composition and function of the intestinal microbiota. Modulation of the microbiota by antibiotics also alters bile acid and glucose metabolism in mice. Hence, we hypothesized that short term administration of oral antibiotics in humans would affect fecal microbiota composition and subsequently bile acid and glucose metabolism. METHODS: In this single blinded randomized controlled trial, 20 male obese subjects with metabolic syndrome were randomized to 7 days of amoxicillin 500mg t.i.d. or 7 days of vancomycin 500mg t.i.d. At baseline and after 1 week of therapy, fecal microbiota composition (Human Intestinal Tract Chip phylogenetic microarray), fecal and plasma bile acid concentrations as well as insulin sensitivity (hyperinsulinemic euglycemic clamp using [6,6-2H2]-glucose tracer) were measured. RESULTS: Vancomycin reduced fecal microbial diversity with a decrease of gram-positive bacteria (mainly Firmicutes) and a compensatory increase in gram-negative bacteria (mainly Proteobacteria). Concomitantly, vancomycin decreased fecal secondary bile acids with a simultaneous postprandial increase in primary bile acids in plasma (p
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