Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 449982
Title The effect of dietary hydroxyproline and dietary oxalate on urinary oxalate excretion in cats
Author(s) Dijcker, J.C.; Plantinga, E.A.; Thomas, D.G.; Queau, Y.; Biourge, V.C.; Hendriks, W.H.
Source Journal of Animal Science 92 (2014). - ISSN 0021-8812 - p. 577 - 584.
DOI https://doi.org/10.2527/jas.2013-6178
Department(s) Animal Nutrition
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2014
Keyword(s) lactic-acid bacteria - oxalobacter-formigenes - primary hyperoxaluria - feline uroliths - adult cats - calcium - rats - dogs - metabolism - canine
Abstract In humans and rodents, dietary hydroxyproline (hyp) and oxalate intake affect urinary oxalate (Uox) excretion. Whether Uox excretion occurs in cats was tested by feeding diets containing low oxalate (13 mg/100g DM) with high (Hhyp-Lox), moderate (Mhyp-Lox), and low hyp (Lhyp-Lox) concentrations (3.8, 2.0 and 0.2 g/100g DM, respectively), and low hyp with high oxalate (93 mg/100g DM; Lhyp-Hox) to 8 adult, female cats in a 48-d study using a Latin square design. Cats were randomly allocated to 1 of the four 12-d treatment periods and fed according to individual energy needs. Feces and urine were collected quantitatively using modified litter boxes during the final 5 d of each period. Feces were analyzed for oxalate and Ca, and urine for specific density, pH, oxalate, Ca, P, Mg, Na, K, ammonia, citrate, urate, sulphate, and creatinine. Increasing hyp intake (0.2, 2.0, and 3.8 g/100g DM) resulted in increased Uox excretion (Lhyp-Lox vs. Mhyp-Lox vs. Hhyp-Lox, P <0.05), and the linear dose-response equation was: Uox (mg ¿d(-1)) = 5.62 + 2.10 x g hyp intake/d (r(2) = 0.56; P <0.001). Increasing oxalate intake from 13 to 93 mg/100g DM did not affect Uox excretion, but resulted in an increase in fecal oxalate output (P <0.001) and positive oxalate balance (32.20 ± 2.06 mg¿d(-1)). The results indicate that the intestinal absorption of the supplemental oxalate, and thereby its contribution to Uox, was low (5.90 ± 5.24%). Relevant increases in endogenous Uox excretion were achieved by increasing dietary hyp intake. The hyp-containing protein sources should be minimized in Ca ox urolith preventative diets until their effect on Uox excretion is tested. The oxalate content (up to 93 mg/100g DM) in a diet with moderate Ca content does not contribute to Uox content.
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