Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 450347
Title Assuring safety without animal testing: the case for the human testis in vitro
Author(s) Chapin, R.E.; Boekelheide, K.; Cortvrindt, R.; Duursen, M. van; Gant, T.; Jegou, B.; Marczylo, E.; Pelt, A.M. van; Post, J.N.; Roelofs, M.J.; Schlatt, S.; Teerds, K.J.; Toppari, J.; Piersma, A.H.
Source Reproductive Toxicology 39 (2013). - ISSN 0890-6238 - p. 63 - 68.
Department(s) Human and Animal Physiology
Publication type Refereed Article in a scientific journal
Publication year 2013
Keyword(s) testicular dysgenesis syndrome - spermatogonial stem-cells - collagen gel matrix - agar-culture-system - leydig-cells - germ-cells - sertoli-cells - invitro differentiation - aromatic-hydrocarbons - 3-dimensional culture
Abstract From 15 to 17 June 2011, a dedicated workshop was held on the subject of in vitro models for mammalian spermatogenesis and their applications in toxicological hazard and risk assessment. The workshop was sponsored by the Dutch ASAT initiative (Assuring Safety without Animal Testing), which aims at promoting innovative approaches toward toxicological hazard and risk assessment on the basis of human and in vitro data, and replacement of animal studies. Participants addressed the state of the art regarding human and animal evidence for compound mediated testicular toxicity, reviewed existing alternative assay models, and brainstormed about future approaches, specifically considering tissue engineering. The workshop recognized the specific complexity of testicular function exemplified by dedicated cell types with distinct functionalities, as well as different cell compartments in terms of microenvironment and extracellular matrix components. This complexity hampers quick results in the realm of alternative models. Nevertheless, progress has been achieved in recent years, and innovative approaches in tissue engineering may open new avenues for mimicking testicular function in vitro. Although feasible, significant investment is deemed essential to be able to bring new ideas into practice in the laboratory. For the advancement of in vitro testicular toxicity testing, one of the most sensitive end points in regulatory reproductive toxicity testing, such an investment is highly desirable.
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