Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 454669
Title Sub-chronic toxicity study in rats orally exposed to nanostructured silica
Author(s) Zande, M. van der; Vandebriel, R.J.; Groot, M.J.; Kramer, E.H.M.; Herrera Riviera, Z.E.; Rasmussen, K.; Ossenkoppele, J.S.; Tromp, P.; Gremmer, E.R.; Peters, R.J.B.; Hendriksen, P.J.; Marvin, H.J.P.; Hoogenboom, L.A.P.; Peijnenburg, A.A.C.M.; Bouwmeester, H.
Source Particle and Fibre Toxicology 11 (2014). - ISSN 1743-8977
Department(s) BU Toxicology, Novel Foods & Agrochains
BU Contaminants & Toxins
BU Authenticity & Bioassays
Publication type Refereed Article in a scientific journal
Publication year 2014
Keyword(s) in-vivo biodistribution - expression profiles - liver fibrosis - nanoparticles - absorption - elimination - injection - foods - acid - size
Abstract Synthetic Amorphous Silica (SAS) is commonly used in food and drugs. Recently, a consumer intake of silica from food was estimated at 9.4 mg/kg bw/day, of which 1.8 mg/kg bw/day was estimated to be in the nano-size range. Food products containing SAS have been shown to contain silica in the nanometer size range (i.e. 5 – 200 nm) up to 43% of the total silica content. Concerns have been raised about the possible adverse effects of chronic exposure to nanostructured silica.
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