Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 454937
Title Analyzing metabolomics-based challenge tests
Author(s) Vis, D.J.; Westerhuis, J.A.; Jacobs, D.M.; Duynhoven, J.P.M. van; Wopereis, S.; Ommen, B. van; Hendriks, M.M.W.B.; Smilde, A.K.
Source Metabolomics 11 (2015)1. - ISSN 1573-3882 - p. 50 - 63.
DOI https://doi.org/10.1007/s11306-014-0673-7
Department(s) Biophysics
PRI Biometris
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2015
Keyword(s) glucose-tolerance test - insulin sensitivity - mathematical-models - component analysis - plasma metabolome - health - asca - reconstruction - phenotype - discovery
Abstract Challenge tests are used to assess the resilience of human beings to perturbations by analyzing responses to detect functional abnormalities. Well known examples are allergy tests and glucose tolerance tests. Increasingly, metabolomics analysis of blood or serum samples is used to analyze the biological response of the individual to these challenges. The information content of such metabolomics challenge test data involves both the disturbance and restoration of homeostasis on a metabolic level and is thus inherently different from the analysis of steady state data. It opens doors to study the variation of resilience between individuals beyond the classical biomarkers; preferably in terms of underlying biological processes. We review challenge tests in which metabolomics was used to analyze the biological response. Specifically, we describe strategies to perform statistical analyses on the responses and we will show some examples of these strategies applied to a postprandial challenge that was used to study a diet with anti-inflammatory properties. Finally we discuss open issues and give recommendation for further research.
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