Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 455247
Title Valencene oxidase CYP706M1 from Alaska cedar (Callitropsis nootkatensis)
Author(s) Cankar, K.; Houwelingen, A.M.M.L. van; Goedbloed, M.A.; Renirie, R.; Jong, R.M. de; Bouwmeester, H.J.; Bosch, H.J.; Sonke, Th.; Beekwilder, M.J.
Source FEBS Letters 588 (2014)6. - ISSN 0014-5793 - p. 1001 - 1007.
Department(s) BIOS Applied Metabolic Systems
Laboratory of Plant Physiology
Publication type Refereed Article in a scientific journal
Publication year 2014
Keyword(s) essential oil - functional-characterization - ixodes-scapularis - cytochrome-p450 monooxygenase - amblyomma-americanum - yeast expression - acari ixodidae - yellow-cedar - mint mentha - nootkatone
Abstract (+)-Nootkatone is a natural sesquiterpene ketone used in grapefruit and citrus flavour compositions. It occurs in small amounts in grapefruit and is a major component of Alaska cedar (Callitropsis nootkatensis) heartwood essential oil. Upon co-expression of candidate cytochrome P450 enzymes from Alaska cedar in yeast with a valencene synthase, a C. nootkatensis valencene oxidase (CnVO) was identified to produce trans-nootkatol and (+)-nootkatone. Formation of (+)-nootkatone was detected at 144 ± 10 lg/L yeast culture. CnVO belongs to a new subfamily of the CYP706 family of cytochrome P450 oxidases.
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