Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 455411
Title Evidence for a mediatory role of amp-activated protein kinase on the metabolic effects of swimming-induced contractile activity in the fish skeletal muscle
Author(s) Planas, J.V.; Palstra, A.P.; Magnoni, L.M.
Source In: Book of abstracts of the International Congress on the Biology of Fish, 03-07 August 2014, Edinburgh, United Kingdom. - - p. 189 - 189.
Event 11th International Congress on the Biology of Fish, Edinburgh, United Kingdom, 2014-08-03/2014-08-07
Department(s) Wageningen Marine Research
Publication type Abstract in scientific journal or proceedings
Publication year 2014
Abstract AMP-dependent protein kinase (AMPK) is a phylogenetically conserved enzyme that senses changes in the AMP/ATP ratio in cells and, consequently, acts as a “metabolic master switch” mediating the cellular adaptation to environmental or nutritional stress factors. In mammals, AMPK is activated in skeletal muscle by exercise, resulting in increased GLUT4-mediated glucose uptake and utilization. However, little is known regarding the potential mediatory role of AMPK on the metabolic effects of swimming in fish. Our group has recently begun to investigate the metabolic role of AMPK and its regulation by contractile activity in skeletal muscle in fish. Our results indicate that AMPK stimulates the uptake and utilization of glucose in fish skeletal muscle cells by specifically up-regulating the GLUT4-dependent glucose transport machinery as well as the mRNA levels of genes involved in glucose utilization. Importantly, we have obtained evidence for the stimulatory effect of muscle contractile activity, either induced in vivo by swimming or in vitro by electrical stimulation of trout myotubes, on AMPK activity. Therefore, AMPK appears to be an important metabolic sensor in fish skeletal muscle. CAN MARINE FISHERY BY-PRODUCTS REDUCE STRESS RESPONSE IN CULTURED ATLANTIC SALMON? Plante, S.,
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