Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 455857
Title Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle
Author(s) Daetwyler, H.D.; Capitan, A.; Pausch, H.; Stothard, P.; Binsbergen, R. van; Brondum, R.F.; Liao, X.; Djari, A.; Rodriguez, S.C.; Grohs, C.; Esquerré, D.; Bouchez, O.; Rossignol, M.N.; Klopp, C.; Rocha, D.; Fritz, S.; Eggen, A.; Bowman, P.J.; Coote, D.; Chamberlain, A.J.; Anderson, C.L.; Tassel, C.P.; Hulsegge, B.; Goddard, M.E.; Guldbrandsten, B.; Lund, M.S.; Veerkamp, R.F.; Boichard, D.A.; Fries, R.; Hayes, B.J.
Source Nature Genetics 46 (2014). - ISSN 1061-4036 - p. 858 - 865.
DOI https://doi.org/10.1038/ng.3034
Department(s) Animal Breeding and Genomics
Animal Breeding & Genomics
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2014
Keyword(s) boophilus-microplus resistance - mitotic chromosomes - genotype imputation - holstein calves - dairy-cattle - milk-yield - bos-taurus - condensin - mutations - gene
Abstract The 1000 bull genomes project supports the goal of accelerating the rates of genetic gain in domestic cattle while at the same time considering animal health and welfare by providing the annotated sequence variants and genotypes of key ancestor bulls. In the first phase of the 1000 bull genomes project, we sequenced the whole genomes of 234 cattle to an average of 8.3-fold coverage. This sequencing includes data for 129 individuals from the global Holstein-Friesian population, 43 individuals from the Fleckvieh breed and 15 individuals from the Jersey breed. We identified a total of 28.3 million variants, with an average of 1.44 heterozygous sites per kilobase for each individual. We demonstrate the use of this database in identifying a recessive mutation underlying embryonic death and a dominant mutation underlying lethal chrondrodysplasia. We also performed genome-wide association studies for milk production and curly coat, using imputed sequence variants, and identified variants associated with these traits in cattle.
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