Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 477547
Title Green genes: bioinformatics and systems-biology innovations drive algal biotechnology
Author(s) Reijnders, M.J.M.F.; Heck, R.G.A. van; Lam, C.M.C.; Scaife, M.A.; Martins dos Santos, V.A.P.; Smith, A.G.; Schaap, P.J.
Source Trends in Biotechnology 32 (2014)12. - ISSN 0167-7799 - p. 617 - 626.
DOI https://doi.org/10.1016/j.tibtech.2014.10.003
Department(s) Systems and Synthetic Biology
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2014
Keyword(s) protein function prediction - subcellular-localization prediction - metabolic network reconstruction - flux balance analysis - chlamydomonas-reinhardtii - lipid-accumulation - expression data - genome - microalgae - sequence
Abstract Many species of microalgae produce hydrocarbons, polysaccharides, and other valuable products in significant amounts. However, large-scale production of algal products is not yet competitive against non-renewable alternatives from fossil fuel. Metabolic engineering approaches will help to improve productivity, but the exact metabolic pathways and the identities of the majority of the genes involved remain unknown. Recent advances in bioinformatics and systems-biology modeling coupled with increasing numbers of algal genome-sequencing projects are providing the means to address this. A multidisciplinary integration of methods will provide synergy for a systems-level understanding of microalgae, and thereby speed up the improvement of industrially valuable strains. In this review we highlight recent advances, challenges, their application in microalgae research, and their potential.
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