Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 477858
Title Mining the Phytophthora infestans genome for metalloproteases
Author(s) Schoina, C.; Bouwmeester, K.; Seidl, M.F.; Meijer, H.J.G.; Govers, F.
Source In: Book of Abstracts Oomycete Molecular Genetics Network Meeting. - - p. 31 - 32.
Event 2014 OMGN Meeting, Norwich, UK, 2014-07-02/2014-07-04
Department(s) Laboratory of Phytopathology
Publication type Abstract in scientific journal or proceedings
Publication year 2014
Abstract Phytophthora infestans is a notorious plant pathogenic oomycete that causes late blight of potato and tomato. The molecular mechanisms exploited by P. infestans in order to circumvent host defence are not fully understood. In several pathogens, proteases are known that can modify host proteins and in this way, play an important role in virulence. Metalloproteases (MPs) are named after the presence of a metal ion at their catalytic site. In mammalian systems, members of the Matrix Metalloprotease (MMP) family and A Disintegrin And Metalloprotease (ADAM) family of MPs have been reported to modify transmembrane proteins during a process called ectodomain shedding. In order to study the potential role of MPs in Phytophthora virulence, an inventory of P. infestans MPs was made based on genome mining. The predicted gene models were verified using ESTs and transcriptomics data. This resulted in a total of 105 P. infestans MP genes that could be classified into 20 different MP families. However, none of the P. infestans MPs could be grouped into either the ADAM or MMP family. Further analyses of the domain compositions and phylogenetic relationships will give 32 insight into the evolution of MPs in P. infestans and related oomycetes. Expression profiles of P. infestans MPs during various growth and infection stages of P. infestans will be obtained from existing transcriptomics data in order to select candidates for functional analysis.
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