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Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

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Record number 477869
Title Genomic rearrangements drive effector evolution in Verticillium dahliae
Author(s) Faino, L.; Seidl, M.F.; Berg, G.C.M. van den; Datema, E.; Janssen, A.; Wittenberg, A.; Thomma, B.P.H.J.
Source In: Book of Abstracts XVI International Congress on Molecular Plant-Microbe Interactions. - - p. 57 - 57.
Event XVI International Congress on Molecular Plant-Microbe Interactions, Rhodes, Greece, 2014-07-06/2014-07-10
Department(s) Laboratory of Phytopathology
Publication type Abstract in scientific journal or proceedings
Publication year 2014
Abstract P114 - Verticillium dahliae is the causal agent of tomato vascular wilt disease. While race 1 isolates express the Ave1 effector that is recognized by the tomato Ve1 immune receptor, race 2 isolates lacks this effector that was identified based on comparative genomics. Comparative genomics further revealed extensive genomic rearrangements between V. dahliae strains leading to lineage-specific regions involved in virulence and niche adaptation. To understand the role of rearrangements in effector evolution between V. dahliae strains, we re- sequenced the ~37 Mb genome of V. dahliae strain JR2 using PacBio and assembled a gapless genome which was aligned to the assembly of strain Ls17 and synteny breakpoints were identified. Subsequently, we assessed the genomic localizations of in planta-induced genes and we prove that virulence genes localize in lineage- specific regions and these regions are in close proximity to genomic rearrangements. Furthermore, we focused on the well-characterized effector Ave1 which localizes in a region were rearrangements occur. Aligning of Illumina reads of 10 V. dahliae strains to the gapless JR2 genome revealed that the Ave1 locus was lost multiple times during evolution.
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