Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 482702
Title Regenerative toxicology: the role of stem cells in the development of chronic toxicities
Author(s) Canovas-Jorda, D.; Louisse, J.; Pistollato, F.; Zagoura, D.; Bremer, S.
Source Expert Opinion on Drug Metabolism and Toxicology 10 (2014)1. - ISSN 1742-5255 - p. 39 - 50.
Department(s) Toxicology
Publication type Refereed Article in a scientific journal
Publication year 2014
Keyword(s) hippocampal synaptic plasticity - hepatic progenitor cells - chronic liver-injury - adult neurogenesis - in-vitro - propofol anesthesia - alagille-syndrome - ductular reaction - adjuvant therapy - oxidative stress
Abstract Introduction: Human stem cell lines and their derivatives, as alternatives to the use of animal cells or cancer cell lines, have been widely discussed as cellular models in predictive toxicology. However, the role of stem cells in the development of long-term toxicities and carcinogenesis has not received great attention so far, despite growing evidence indicating the relationship of stem cell damage to adverse effects later in life. However, testing this in vitro is a scientific/technical challenge in particular due to the complex interplay of factors existing under physiological conditions. Current major research programs in stem cell toxicity are not aiming to demonstrate that stem cells can be targeted by toxicants. Therefore, this knowledge gap needs to be addressed in additional research activities developing technical solutions and defining appropriate experimental designs. Areas covered: The current review describes selected examples of the role of stem cells in the development of long-term toxicities in the brain, heart or liver and in the development of cancer. Expert opinion: The presented examples illustrate the need to analyze the contribution of stem cells to chronic toxicity in order to make a final conclusion whether stem cell toxicities are an underestimated risk in mechanism-based safety assessments. This requires the development of predictive in vitro models allowing the assessment of adverse effects to stem cells on chronic toxicity and carcinogenicity.
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