Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 483072
Title Favourable effects of consuming a Palaeolithic-type diet on characteristics of the metabolic syndrome: a randomized controlled pilot-study
Author(s) Boers, I.; Muskiet, F.A.J.; Berkelaar, E.; Schut, E.; Penders, R.; Hoenderdos, K.; Jong, M.C. de; Wichers, H.J.
Source Lipids in Health and Disease 13 (2014). - ISSN 1476-511X - 13 p.
DOI https://doi.org/10.1186/1476-511X-13-160
Department(s) FBR Fresh Supply Chains
Publication type Refereed Article in a scientific journal
Publication year 2014
Keyword(s) obese postmenopausal women - mediterranean-like diet - ischemic-heart-disease - hunter-gatherer - cardiovascular-disease - life-style - macronutrient - 21st-century - metaanalysis - individuals
Abstract Background The main goal of this randomized controlled single-blinded pilot study was to study whether, independent of weight loss, a Palaeolithic-type diet alters characteristics of the metabolic syndrome. Next we searched for outcome variables that might become favourably influenced by a Paleolithic-type diet and may provide new insights in the pathophysiological mechanisms underlying the metabolic syndrome. In addition, more information on feasibility and designing an innovative dietary research program on the basis of a Palaeolithic-type diet was obtained. Methods Thirty-four subjects, with at least two characteristics of the metabolic syndrome, were randomized to a two weeks Palaeolithic-type diet (n¿=¿18) or an isoenergetic healthy reference diet, based on the guidelines of the Dutch Health Council (n¿=¿14). Thirty-two subjects completed the study. Measures were taken to keep bodyweight stable. As primary outcomes oral glucose tolerance and characteristics of the metabolic syndrome (abdominal circumference, blood pressure, glucose, lipids) were measured. Secondary outcomes were intestinal permeability, inflammation and salivary cortisol. Data were collected at baseline and after the intervention. Results Subjects were 53.5 (SD9.7) year old men (n¿=¿9) and women (n¿=¿25) with mean BMI of 31.8 (SD5.7) kg/m2. The Palaeolithic-type diet resulted in lower systolic blood pressure (-9.1 mmHg; P¿=¿0.015), diastolic blood pressure (-5.2 mmHg; P¿=¿0.038), total cholesterol (-0.52 mmol/l; P¿=¿0.037), triglycerides (-0.89 mmol/l; P¿=¿0.001) and higher HDL-cholesterol (+0.15 mmol/l; P¿=¿0.013), compared to reference. The number of characteristics of the metabolic syndrome decreased with 1.07 (P¿=¿0.010) upon the Palaeolithic-type diet, compared to reference. Despite efforts to keep bodyweight stable, it decreased in the Palaeolithic group compared to reference (-1.32 kg; P¿=¿0.012). However, favourable effects remained after post-hoc adjustments for this unintended weight loss. No changes were observed for intestinal permeability, inflammation and salivary cortisol. Conclusions We conclude that consuming a Palaeolithic-type diet for two weeks improved several cardiovascular risk factors compared to a healthy reference diet in subjects with the metabolic syndrome.
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