Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 488993
Title Lectin receptor kinase; sentinels in defense against plant pathogens
Author(s) Wang, Y.; Govers, F.; Bouwmeester, K.
Source In: Book of Abstracts Keystone Symposia on Molecular and Cellular Biology. - - p. 43 - 43.
Event Keystone Symposia on Molecular and Cellular Biology 2015, Taos, New Mexico, 2015-02-08/2015-02-13
Department(s) Laboratory of Phytopathology
EPS-2
Publication type Abstract in scientific journal or proceedings
Publication year 2015
Abstract Plant breeders continuously face the challenge to obtain new cultivars with adequate levels of resistance to a variety of pathogens. In recent years, we identified a novel type of immune receptors that could be employed as disease resistance components towards both Phytophthora and bacterial pathogens. This resistance is mediated by cell surface receptors belonging to the family of L-type lectin receptor kinases (LecRKs). LecRKs are wide-spread in plants, and justifies exploitation of LecRKs as novel sources of crop resistance. The LecRK multi-gene family in Arabidopsis consists of 45 members, and their individual role in defense was determined in a genome-wide phenotypic analysis of T-DNA insertion mutants in infection assays. We found that multiple LecRKs play a role in resistance to a variety of plant pathogens, and that overexpression of various LecRKs enhances disease resistance. In addition, we screened for LecRK-lnteracting-Proteins (LIPs) using mass spectrometry. LecRK interaction was confirmed for one of the candidates, LIP1, in co-immunoprecipitation assays. Further functional analysis showed that Arabidopsis Lip1 mutants are compromised in Phytophthora resistance in a similar fashion as LecRK mutant lines. Understanding how LecRK-mediated resistance is functioning is crucial to design novel resistance in crops against Phytophthora and bacterial plant pathogens.
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