Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 489724
Title Biological processes induced by ZnO, Amoxicillin, Rye and Fructooligosaccharides in cultured Intestinal Porcine Epithelial Cells : VDI-4; In-vitro tests 2013-2014
Author(s) Hulst, M.M.; Hoekman, A.J.W.; Wijers, I.; Schokker, D.; Smits, M.A.
Source Wageningen : Wageningen UR Livestock Research (Livestock Research report 882) - 42
Department(s) Animal Breeding & Genomics
Wageningen Livestock Research
Infection Biology
Publication type Research report
Publication year 2015
Keyword(s) in vitro - bioassays - epithelium - livestock - feed additives - genes - immunology - in vitro - biotesten - epitheel - vee - voedertoevoegingen - genen - immunologie
Categories Immunology
Abstract The objective of this study was to develop an in-vitro bioassay using cultured Intestinal Porcine Epithelial Cells (IPEC-J2) and evaluate the capability of this assay to predict enterocyte-specific physiological and immunological processes induced by nutrients/additives in the intestines of farm animals. Responses to five nutrients/feed-additives, similar to those studied in animal trials, performed in the Feed4Foodure framework, were measured by gene expression analysis of IPEC-J2 cells either under stressed (Salmonella) or non-stressed conditions. Response genes were analysed using bioinformatics web-tools in order to identify dominant biological processes induced by these nutrients/feed-additives and to predict key-genes/proteins important for regulation of these biological proc
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